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Biochemie I

AG Prof. Dr. Stefan Höning

  • Membrane protein trafficking in mammalian cells

At any time, our cells need to transport newly synthesized proteins from the endoplasmic reticulum to their site of function. Simultaneously, proteins and other macromolecules are taken up from the exterior of the cell and also transported to different intracellular destinations. Our work focuses on protein factors that belong to the intracellular sorting machinery, and we try to understand how they interact with membrane proteins, how they organise various transport steps and how their function is regulated. This work has implications for a number of important diseases such as familial hypercholesterolemia, forms of anemia, hypopigmentation, the Hermansky-Pudlak syndrome and the lysosomal storage diseases.

shoeningSpamProtectionuni-koeln.de

AG Prof. Dr. Ludwig Eichinger

  • Autophagy and autophagy related processes studied in the model organism Dictyostelium discoideum

ludwig.eichingerSpamProtectionuni-koeln.de

AG Prof. Dr. Gernot Glöckner

  • Evolutionary, comparative and functionale genomics
  • basic requirements for differentiation processes
  • regulatory networks during development
  • evolution of different morphotypes

gernot.gloecknerSpamProtectionuni-koeln.de

AG Dr. Muhammad Sajid Hussain

  • Mikrozephalie und Zentrosom

The notable trend during mammalian evolution is dramatic expansion in brain size. Of particular interest is the vast expanse of the cerebral cortex, which is believed to have resulted in our ability to perform higher cognitive functions and is a feature that distinguishes humans from our fellow primates. Such anatomical changes must have a basis in genetic alterations. Primary microcephaly (MCPH) is a neurodevelopmental disorder resulted in diminution of brain growth in utero.

We have the aim to identify novel genes in a pool of MCPH families collected from remote regions of Pakistan and to elucidate their role in the etiology of this disease by using State-of-the-Art techniques at a genetic and biochemical level.

mhussainSpamProtectionuni-koeln.de