AG Brodesser(Lipidomics Facility)
In the long term the Facility plans to expand its service towards more general metabolomics applications by integrating metabolites of the glycolysis, the citric acid cycle and the pentose phosphate pathway into the set of service analyses.
Resistenzen und Resistenzmechanismen von gram-negativen Bakterien und medizinisch wichtigen Pilzen
AG Hartmann
the role of IFN-alpha during HIV-Infection; identification and characterization of mycobacteriophage derived host shut-off proteins
Pia.hartmann@uk-koeln.de
Cell Death and Immunity, tissue homeostasis, mitochondrial regulation of cell death and immunity and its impact on the fate of the tissue
Antibody-based therapeutic, aims of our research are:
- production of recombinant S. aureus proteins and monoclonal antibodies for active and passive vaccination against S. aureus infections
- modification of bacteriophage and viral particles to become vaccines or vectors for gene therapy
- selection of antibody fragments via phage display to select for inhibitors of Staphylococcus aureus infections
- development of bacterial strains for the diagnosis and treatment of tumor burdens by a combination of immunotoxin secretion and live imaging
TNF Signaling, NADPH oxidases, and Ceramide Generating Enzymes in Immunity to Infection and Cancer. In particular we currently pursue the following projects:
1) Individual roles of specific Nox enzymes in infection and cell death (Wiegmann, Yazdanpanah).
2) Individual roles of specific ceramide synthases and ceramides of distinct acyl chain lengths in TNF receptor signaling and ageing (Pongratz, Brodesser, Wiegmann).
3) Biological and biochemical characterization of neutral sphingomyelinase 3 (nSMase3) (Kwasny, Wiegmann)
4) Role of TNF-R1 adaptor protein FAN in cancer cell migration and metastasis (Böcke, Carstens, Buning)
AG Krut
Interaction of Staphylococcus aureus with professional and nonprofessional phagocytes
Identification and characterization of mycobacterial genes required for intracellular survival in macrophages
Inflammation, cell death and phagosomal processing in the innate immune response against intracellular bacterial pathogens
Regulation of anti-bacterial immunity by reactive oxygen species
Acinetobacter baumannii and Staphylococcus aureus
Innate and adaptive immunity in vivo