Institut für Medizinische Mikrobiologie, Immunologie & Hygiene
AG Hamprecht
Resistenzen und Resistenzmechanismen von gram-negativen Bakterien und medizinisch wichtigen Pilzen
uk-koeln.deAG Kashkar
Cell Death and Immunity, tissue homeostasis, mitochondrial regulation of cell death and immunity and its impact on the fate of the tissue
AG Klimka
Antibody-based therapeutic, aims of our research are:
- production of recombinant S. aureus and A. baumannii proteins and monoclonal antibodies for active and passive vaccination against infections
- modification of bacteriophage and viral particles to become vaccines or vectors for gene therapy
- selection of antibody fragments and peptides via phage display to select for inhibitors of Staphylococcus aureus infections
- generation of monoclonal antibodies for the development of diagnostic kits to detect microbial target structures
AG Krönke
TNF Signaling, NADPH oxidases, and Ceramide Generating Enzymes in Immunity to Infection and Cancer. In particular we currently pursue the following projects:
1) Individual roles of specific Nox enzymes in infection and cell death (Wiegmann, Yazdanpanah).
2) Individual roles of specific ceramide synthases and ceramides of distinct acyl chain lengths in TNF receptor signaling and ageing (Pongratz, Brodesser, Wiegmann).
3) Biological and biochemical characterization of neutral sphingomyelinase 3 (nSMase3) (Kwasny, Wiegmann)
4) Role of TNF-R1 adaptor protein FAN in cancer cell migration and metastasis (Böcke, Carstens, Buning)
AG Krut
Interaction of Staphylococcus aureus with professional and nonprofessional phagocytes
AG Plum
Identification and characterization of mycobacterial genes required for intracellular survival in macrophages
AG Robinson
Inflammation, cell death and phagosomal processing in the innate immune response against intracellular bacterial pathogens
AG Schramm
Regulation of anti-bacterial immunity by reactive oxygen species