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Institut für Medizinische Mikrobiologie, Immunologie & Hygiene

AG Brodesser(Lipidomics Facility)

In the long term the Facility plans to expand its service towards more general metabolomics applications by integrating metabolites of the glycolysis, the citric acid cycle and the pentose phosphate pathway into the set of service analyses.


Resistenzen und Resistenzmechanismen von gram-negativen Bakterien und medizinisch wichtigen Pilzen


AG Hartmann

the role of IFN-alpha during HIV-Infection; identification and characterization of mycobacteriophage derived host shut-off proteins


Cell Death and Immunity, tissue homeostasis, mitochondrial regulation of cell death and immunity and its impact on the fate of the tissue


Antibody-based therapeutic, aims of our research are:

  • production of recombinant S. aureus and A. baumannii proteins and monoclonal antibodies for active and passive vaccination against infections
  • modification of bacteriophage and viral particles to become vaccines or vectors for gene therapy
  • selection of antibody fragments and peptides via phage display to select for inhibitors of Staphylococcus aureus infections
  • generation of monoclonal antibodies for the development of diagnostic kits to detect microbial target structures


TNF Signaling, NADPH oxidases, and Ceramide Generating Enzymes in Immunity to Infection and Cancer. In particular we currently pursue the following projects:

1) Individual roles of specific Nox enzymes in infection and cell death (Wiegmann, Yazdanpanah).

2) Individual roles of specific ceramide synthases and ceramides of distinct acyl chain lengths in TNF receptor signaling and ageing (Pongratz, Brodesser, Wiegmann).

3) Biological and biochemical characterization of neutral sphingomyelinase 3 (nSMase3) (Kwasny, Wiegmann)

4) Role of TNF-R1 adaptor protein FAN in cancer cell migration and metastasis (Böcke, Carstens, Buning)


AG Krut

Interaction of Staphylococcus aureus with professional and nonprofessional phagocytes


Identification and characterization of mycobacterial genes required for intracellular survival in macrophages


Inflammation, cell death and phagosomal processing in the innate immune response against intracellular bacterial pathogens


Regulation of anti-bacterial immunity by reactive oxygen species


Acinetobacter baumannii and Staphylococcus aureus


Innate and adaptive immunity in vivo