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Cologne Center for Genomics (CCG)

Research Group Dermatogenetics

PD Dr. Hans Christian Hennies 

  • Search for mutations underlying rare genetic skin diseases
  • Deciphering the genetic basis of Dupuytren’s disease using genome-wide association studies, high-throughput sequencing and transcriptome analysis
  • Identifying therapeutic targets for Dupuytren’s disease using functional characterisation of candidate DNA variants
  • Generating advanced cellular models for genetic skin diseases
  • Characterising properties of keratinocytes derived from human induced pluripotent stem cells and their abilities to serve as disease models
  • Development of topical therapies for rare monogenic skin diseases using nanoparticle-mediated enzyme substitution


Research Group Epilepsy Genetics

Dr. Thomas Sander 

  • Molecular genetic dissection of Genetic Generalized Epilepsies (GGEs) by genome-wide linkage and association studies
  • Search for novel epilepsy genes by whole exome sequencing and copy number analyses
  • Epigenetic profiling of molecular key pathways of epileptogenesis
  • Deciphering of genetic and epigenetic biomarkers predicting therapy outcomes of common focal and generalized epilepsies


Research Group Functional Epigenomics

Prof. Dr. Dr. Michal Ruth Schweiger 

  • Translational epigenomics
  • Identification of epigenetic biomarkers for therapy resistance in oncology
  • Regulation of repetitive noncoding RNA and their impact on cellular physiology
  • Mechanisms of genomic instability in cancer
  • Epigenetic regulation of alternative splicing events under stress and in disease
  • Hereditary tumor predisposition syndromes


Research Group Genomics

Prof. Dr. Peter Nürnberg

  • Development and implementation of new methods for disease gene discovery
  • Molecular basis of disturbed neurogenesis in primary microcephaly
  • Role of Wnt signaling in the etiology of Filippi syndrome and ectrodactyly ectodermal dysplasia


Research Group Statistical Genetics and Bioinformatics

Prof. Dr. Michael Nothnagel 

  • Development and application of statistical methods for single- and multiple-layer analysis of genomic data; ongoing biological and medical collaborations
  • Description of genomic, spatial and phylogeographic patterns of human genetic variation, including ancient DNA
  • Methods development and addressing of statistical issues in forensic statistics, including relationship identification and phenotype prediction