AG Prof. Dr. Monique Aumailley
- Wechselwirkungen zwischen Zellen und der extrazellulären Matrix
- Modulation der zellulären Aktivitäten durch Laminin-Isoformen
- Laminin-bindende Integrine und andere Rezeptoren kontrollierte Migration von EpithelzellenDie Rolle von Lamininen in der Bildung und Umbau von Epithelbasalmembran
- Die Rolle von Rho GTPasen in "Laminin signaling"
AG Prof. Dr. Franz-Georg Hanisch
Our research efforts focus on mucin-type O-glycosylation, initially concentrating on tumor-associated carbohydrate antigens, later in a more general biological context. As model protein we investigated the structural aspects of MUC1 glycosylation, the first human mucin described and one of the most promising tumor markers with impact in diagnosis and in immunotherapy. Beyond a mere profiling of glycans expressed on the mucin from the normal (lactating) breast or from breast cancer cells, we tried to determine the changes in density and the sites of O-glycosylation associated with cancer development. In later studies we looked for the influence of the sites glycosylated on MUC1 tandem repeat peptides on their immunological properties (processing in the class I and class II pathways) to prepare the basis for a vaccine development. Other projects focus on the investigation of additional rare O-Glycosylation-Types and their control by peptidic alements as well as on development of new techniques with regard to glycomics in SDS-gel-based platforms and to glycoproteomic approaches aiming at the improvement of O-glycoprotein identification.
AG Dr. Ursula Hartmann
We are interested in a certain family of matrix proteins, the so called EC domain proteins. The members of these family are multidomain proteins characterised by a domain which contains two calcium-binding EF-hand motifs and was therefore termed extracellular calcium-binding (EC) domain. The prototype of these family is BM-40 (also called osteonectin or SPARC), a glycoprotein that has been implicated in cell growth and tissue remodeling. It. was the first extracellular protein that was shown to contain EF-hand motifs, demonstrating that this motif is not confined to intracellular proteins. EC domains are also found in the proteins SC1/hevin, tsc36 and testican/Spock where they are always preceded by a FS domain. During the last years we could identify four novel members of the EC domain family. Two share the domain organisation of testican/Spock and hence were termed testican-2 and testican-3. The two other proteins show a unique domain organisation and were termed SMOC-1 and SMOC-2, where SMOC stands for Secreted Modular Calcium-binding protein.
Charakterisierung extrazellulärer, Calcium-bindender Proteine, Molekulare Neurobiologie
AG PD Dr. Markus Plomann
Zelluläre Neurobiologie, Intrazellulärer Vesikeltransport
AG Prof. Dr. Raimund Wagener
Struktur und Funktion von VWA-Domänen enthaltenden Proteinen der extrazellulären Matrix
assoz. AG Univ.-Prof. Dr. Bent Brachvogel
- Klinik für Kinder und Jugendmedizin, exp. Neonatologie
assoz. AG Univ.-Prof. Dr. Manuel Koch
Institut für exp. Zahnmedizin und orale muskuloskeletale Biologie