Research Area A: Mitochondrial Dysfunction in Aging and Neurodegeneration
Project leaders: Prof. Dr. Elena I. Rugarli, Prof. Dr. Thomas Langer
Key objectives of research area C are to investigate:
- mechanisms that maintain mitochondrial genome integrity during aging
- mechanisms that ensure the fidelity of mitochondrial gene expression and regulate respiratory capacity during aging
- key components and signaling pathways mediating increased longevity caused by mitochondrial dysfunction
- the protective role of mitochondrial quality control mechanisms counteracting aging-associated loss of mitochondrial activities
- pathogenic mechanisms of neurodegenerative diseases caused by impaired mitochondrial quality control to define novel therapeutic targets
Principal investigators:
- Prof. Dr. Aleksandra Trifunovic
aleksandra.trifunovic[at]uk-koeln.de
- Dr. Matteo Bergami
matteo.bergami[at]uk-koeln.de
- Prof. Dr. Rudolf J. Wiesner
Rudolf.Wiesner[at]uni-koeln.de