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Research Area B: Proteostasis in Aging- associated Diseases

Project leaders: Prof. Dr. Thomas Benzing, Prof. Dr. Thorsten Hoppe

 

Key objectives of research area C are to investigate:

  • regulators and ubiquitin-dependent degradation pathways that control age-related proteotoxicity and aging
  • mechanisms that contribute to tissue-specificity of proteostasis networks
  • the role of PQC pathways in intracellular organelles in stress and aging
  • how defects in proteostasis cause protein aggregation, kidney defects, and neurodegeneration

 

Principal Investigators:

  • Prof. Dr. Aleksandra Trifunovic

aleksandra.trifunovic[at]uk-koeln.de

  • Dr. David Vilchez

dvilchez[at]uni-koeln.de

  • Prof. Dr. Thomas Benzing

thomas.benzing[at]uk-koeln.de

  • Dr. Markus Schubert

markus.schubert[at]uk-koeln.de

  • Dr. Marco Herling

marco.herling[at]uk-koeln.de