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Cologne Center for Genomics (CCG)

Research Group Dermatogenetics

PD Dr. Hans Christian Hennies 

  • Search for mutations underlying rare genetic skin diseases
  • Generating advanced cellular models for genetic skin diseases

We have been analysing autosomal recessive congenital ichthyosis (ARCI), which can be caused by mutations in the genes TGM1, ALOX12B, ALOXE3, Ichthyin, ABCA12, and CYP4F22, and for which mutations in even further genes must exist. The positional cloning approach using linkage analysis and especially autozygosity mapping with consanguineous families is promising to identify new loci underlying the disease.

  • 3D skin models for congenital ichthyosis

We are interested in the pathology of alopecia areata, a frequent and often chronic disorder of the hair follicle with a strong genetic susceptibility towards autoimmune disease. We are using a concerted strategy of characterizing the basis for hair loss in an established animal model, the Dundee epidermal bald (DEB) rat, and searching genetic factors underlying susceptibility to alopecia areata in humans primarily using an affected sib pair study design.

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Research Group Epilepsy Genetics

Dr. Thomas Sander 

  • Molecular genetic dissection of Genetic Generalized Epilepsies (GGEs) by genome-wide linkage and association studies
  • Search for novel epilepsy genes by whole exome sequencing and copy number analyses
  • Epigenetic profiling of molecular key pathways of epileptogenesis
  • Deciphering of genetic and epigenetic biomarkers predicting therapy outcomes of common focal and generalized epilepsies

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Research Group Functional Epigenomics

Prof. Dr. Dr. Michal Ruth Schweiger 

  • Translational epigenomics
  • Identification of epigenetic biomarkers for therapy resistance in oncology
  • Regulation of repetitive noncoding RNA and their impact on cellular physiology
  • Mechanisms of genomic instability in cancer
  • Epigenetic regulation of alternative splicing events under stress and in disease
  • Hereditary tumor predisposition syndromes

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Research Group Genomics

Prof. Dr. Peter Nürnberg

  • Development and implementation of new methods for disease gene discovery
  • Molecular basis of disturbed neurogenesis in primary microcephaly
  • Role of Wnt signaling in the etiology of Filippi syndrome and ectrodactyly ectodermal dysplasia

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Research Group Statistical Genetics and Bioinformatics

Prof. Dr. Michael Nothnagel 

  • Development and application of statistical methods for single- and multiple-layer analysis of genomic data; ongoing biological and medical collaborations
  • Description of genomic, spatial and phylogeographic patterns of human genetic variation, including ancient DNA
  • Methods development and addressing of statistical issues in forensic statistics, including relationship identification and phenotype prediction

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