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The importance of biodiversity for human medicine

This content is an excerpt from the systematic paper review by Paul Henkelmann.

 

Climate change and the associated collapse of ecosystems and loss of biodiversity threaten not only the natural environment and our livelihoods, but also one of the most important sources of knowledge in human medicine: the evolutionary richness of nature and its living organisms.

Numerous examples show that research into plants, animals and microorganisms has led to significant medical breakthroughs. These include the development of medicines from plants and technological innovations through microbial mechanisms (e.g. CRISPR-Cas9, PCR). The loss of biodiversity therefore not only jeopardizes ecological balances, but also future medical innovations.

Biodiversity includes not only the diversity of species, but also genetic differences within species and their ecological functions. Today, the loss of this diversity is reaching historic proportions: since 1970, the populations of large vertebrates have declined by 69 %, and many biodiversity hotspots have lost over 70 % of their natural vegetation. Conservation measures are often ineffective as they are mostly voluntary and lack binding policies and public support (e.g. the goals of the Paris Agreement). Successful projects do have an impact, but are too small in scale. Pioneering technologies such as AI-supported nature conservation planning could open up new perspectives here.

Two key measures are required to effectively counteract the ongoing loss of biodiversity and at the same time safeguard the potential of medical innovations from nature. Firstly, international conservation laws are needed that not only combat direct threats such as poaching, deforestation and the disposal of toxic waste, but also take indirect factors such as climate change into account. Secondly, comprehensive public education and awareness-raising is necessary to create a broad understanding of the importance of biodiversity and thereby build political pressure for sustainable measures. In the long term, only a combination of political regulation and social change can effectively halt the loss of biodiversity.

In conclusion, it can be said that Biodiversity holds outstanding potential for medical research and care. Its progressive loss jeopardizes an indispensable source of biological knowledge and medical innovation. More consistent protection of biodiversity is therefore essential to ensure future discoveries and advances in medicine and thus also our resilience and survival in the long term.

Table 1: Examples of plant-derived drugs that are relevant for medicine.

Drug

Origin

Mechanism

Use in medicine

Acetylsalicylic acid

Filipendula ulmaria

inhibition of cyclooxygenase

analgesic; anti-inflammatory; antipyretic; Thromboaggregation inhibitor

Curare derivatives

Menispermaceae

competitive antagonist of nicotinic acetylcholine receptors

muscle relaxant during surgery

Coumarin derivatives

Melilotus

inhibition of vitamin K

inhibition of blood clotting

Atropine

Atropa belladonna

anticholinergic

Nerve agent treatment; Pesticide poisoning treatment; Slow heart rate treatment

Muscarine

Amanita muscaria

Acetylcholine antagonist

Glaucoma treatment; Ileus treatment

Nicotine

Solanaceae

acetylcholine antagonist

addiction treatment; Parkinson's treatment

Capsaicin

Capsicum

defunctionalization of nociceptors

Analgetic

Digitalis

Digitalis purpurea

inhibition of the sodium-potassium pump

Insufficient heart disease treatment

Table 2: Examples of technologies derived from specific organisms and their use in human medicine.

Species

Process or factor

Technology

Use in medicine and research

Thermophilic bacterium, Thermus aquaticus

Taq DNA polymerase

Polymerase chain reaction (PCR)

Disease diagnosis; pathogen detection; elucidation of the genetic contribution to complex diseases

Different bacteria bacteria

CRISPR, Cas9

CRISPR-Cas9-based gene editing

gene therapy; elucidation of disease pathophysiology; control of mosquito populations and non-native invasive species

Fruit fly, Drosophila melanogaster

 

Model organism

Understanding immune responses to pathogens

Nematode, Caenorhabditis elegans

 

model organism

mechanism of programmed cell death (apoptosis) and embryonic development

Bear, Ursus arctos

Specific regulatory patterns

Medication

Development of new thromboprotective drugs to prevent thromboembolism in immobile patients

Giraffe, Giraffa

Resilience against high blood pressure

Medication

Development of new drugs against chronic high blood pressure

Hummingbird, Trochilidae

Resilience against hyperglycemia

Medication

Development of new drugs against chronic hyperglycemia

Bat, Myotis myotis

Longest relative lifespan of all mammals

Cell cycle regulation

Better understanding and promotion of healthy ageing