Collaborative Research Centers are university research institutions with a duration of up to 12 years. Here, scientists work together across disciplines. In this way, innovative, elaborate and long-term research projects are realized by coordinating and concentrating people and resources at the Faculty of Medicine and enable an institutional focus and structure to be formed in accordance with the Faculty's three main research areas.

The Faculty of Medicine at the University of Cologne currently has 4 Collaborative Research Centers.

Scientists from the Faculty of Medicine at the University of Cologne are also involved in other Collaborative Research Centers and Transregios.